A JAMA article showed that the number of US adults who take prescription drugs increased from 51% to 59% from 1999 to 2012. The prevalence of those taking 5 or more drugs almost doubled during the same timeframe, from 8% to 15%. Large increases were noted for drugs to treat cholesterol, depression, acid reflux, and muscle spasms. The effect was irrespective of age. Please listen carefully to all the side effects mentioned in the TV advertisements for drugs.